Vitamins B: - Biotin deficiency is associated with a decrease in biotinylated histones and an increase in fertility rates (81) - Vitamin B mixture increases methylation level of H3K27 (82)Folate: - Reduced DNA methylation variance in KCNQ1OT1, SNRPN and PEG1 (84) - increased global DNA methylation levels in both embryonic and placental tissues (84)Zinc deficiency is associated with decreased histone H3K4 and global DNA methylation in oocytes (87). The gene discussed is MEST; the disease is nutritional biotin deficiency.