Finally, peripheral neuropathy is common on the ICU and has been shown to increase neurofilament proteins.36 Further studies using multiple neurobiomarkers, such as GFAP, UCH-L1, NSE in combination with functional scores and possibly EMG data could aid in unravelling the specificity of changes and when, and to what extent, NfL increases are of peripheral or central origin. The gene discussed is ENO2; the disease is peripheral neuropathy.