GLI2 and hepatocellular carcinoma: As in hepatocellular carcinoma, circ-ZNF609 inhibits miR-15a-5p/15b-5p expression and then elevates GLI2 (a key protein molecule concerning the Hedgehog pathway) expression, activating the Hedgehog pathway to promote hepatocellular carcinoma (HCC) proliferation and metastasis (He et al., 2020).