Bioinformatics analysis suggested that circ-ZNF609 was bound to miR-181a-5p in immature T-ALL, which by targeting O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (LFNG) to promote leukemogenic potential through the Notch1 signaling pathway in T-ALL (Buratin et al., 2020). This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.