PSMC2 and Familial prostate cancer: Moreover, PSMC2 was also reported to promote proliferation and inhibit apoptosis of glioma cells, and its knockdown halted the development and metastasis of prostate cancer (Chen et al., 2021) and progression of OSCC cells by promoting apoptosis via PI3K/Akt pathway and increasing the expression of pro-apoptotic proteins (Wang et al., 2022).