t (8;21) AML related to the RUNX1-RUNX1T1 (AML1-ETO, AE) fusion gene, accounts for approximately 7% of adult primary AML (Arber et al., 2016; Faber et al., 2016; Papaemmanuil et al., 2016; Döhner et al., 2017). The gene discussed is RUNX1; the disease is acute myeloid leukemia.