TNF and glioblastoma: Nine classical phenotype markers of M0 (allograft inflammatory factor 1), M1 macrophages (IL12 subunit alpha, tumor necrosis factor, nitric oxide synthase 2, and prostaglandin-endoperoxide synthase 2), and M2 macrophages (IL10, CCL163, transforming growth factor-beta 1, and colony-stimulating factor 1R) were analyzed using TCGA LGG–GBM database (Figure 6D).