For example, the cumulative lifetime risk of female BC may be as high as 46–87% for BRCA1 carriers and 38–84% for BRCA2 carriers; the cumulative risks of OC development by the age of 80 years in these carriers are 44 and 17%, respectively (Petrucelli, Daly and Pal, 1993). This evidence concerns the gene BRCA2 and breast cancer.