BRCA1 and cancer: In our cohort we found two kidney cancer cases (1 prevalent and one incident), both with the same BRCA1 PV (rs ID rs80357711) and early onset (before age 50) which is much different (>50 times higher) from the expected average population levels of kindney cancer prevalence, suggesting a possible connection with specific PV of BRCA1 and kidney cancer (chromophobe subtype).