The use of FHs has several limitations, especially in modern societies characterized by individualism, the privacy of health information, mental and/or physical separation of families, and non-biologically related families, which result in the lack of detailed information on family cancers (e.g., age of onset, anatomical location, morphological form, and immunohistochemical properties such as estrogen and progesterone receptor and human epidermal growth factor receptor two status in breast cancer). This evidence concerns the gene PGR and breast cancer.