Importantly, we found that FAM83B was negatively correlated with cisplatin and carboplatin resistance, as well as with the ovarian cancer tumor microenvironment in tumor purity, and related studies also showed that FAM83B suppresses cisplatin resistance and slows ovarian tumor progression (He et al., 2021), indicating that the biological properties of the FAM83 family are not consistent in different tumors. Here, SACK1B is linked to ovarian neoplasm.