CD274 and lung cancer: Shen et al. (2019) demonstrated that the inhibition of ATM could decrease the metastatic potential of cisplatin-resistant lung cancer cells through the JAK/STAT3/PD-L1 pathway. Meanwhile, lanatoside C could induce tumor proliferation and G2/M cell cycle arrest by attenuating the JAK/STAT signaling pathway (Reddy et al., 2019).