Yang et al. (2021) revealed that the RNA methyltransferase NSUN6 could hamper pancreatic cancer development by regulating cell proliferation. Su et al. (2021) demonstrated that NSUN2-mediated m5C modification could facilitate esophageal squamous cell carcinoma development through LIN28B-dependent GRB2 mRNA stabilization. Moreover, Ma et al. (2022) established a database with a comprehensive collection and annotation of RNA 5-methylcytosine, named m5C-Atlas. Here, GRB2 is linked to familial pancreatic carcinoma.