In the univariate analysis, the MTHFR rs1801133 variant was not significantly associated with HTN under various inheritance models [genotypic (OR = 0.75, 95% CI = 0.29–1.95, p = 0.56), dominant (OR = 0.86, 95% CI = 0.35–2.16, p = 0.75), recessive (N/A), co-dominant (OR = 1.33, 95% CI = 1.51–3.48, p = 0.55) and allelic models (OR = 0.80, 95% CI = 0.49–1.62, p = 0.70)]. The gene discussed is MTHFR; the disease is hypertensive disorder.