Loss of NKX2-1 could lead to the recruitment of tumor-associated neutrophils which promote the proliferation of lung squamous cell (Mollaoglu et al., 2018), and high expression of ARNTL2, which could drive metastatic self-sufficiency and predict poor prognosis for LUAD patients (Brady et al., 2016). Here, NKX2-1 is linked to neoplasm.