Fourteen meta-analyses (Ye and Song, 2005; Das et al., 2009; Zintzaras, 2009; Vijayakrishnan and Houlston, 2010; Tang et al., 2013; He et al., 2014a; He et al., 2014b; Ma et al., 2014; Moulik et al., 2014; Tang et al., 2014; Xu and Cao, 2014; Li et al., 2018; Zhao et al., 2018; Wang et al., 2019) reported the individual effects of the GSTM1 and GSTT1 polymorphisms with leukemia risk. This evidence concerns the gene GSTM1 and leukemia.