For example, METTL1, an m7G methyltransferase, has been linked to advanced tumor stage, vascular invasion, and poor prognosis in LIHC patients and facilitates tumor progression through increasing m7G tRNA modification and promoting translation of target mRNAs (Tian et al., 2019; Chen et al., 2021). This evidence concerns the gene METTL1 and neoplasm.