CD8A and neoplasm: We found that high-risk LIHC patients were more inclined to an immunosuppressive state because immune-related pathways (such as natural killer cell-mediated cytotoxicity, antigen processing, and presentation), immune-related function (such as type1/2 IFN response, T-cell co-stimulation, and cytolytic activity), and anti-tumor immune cells (such as activated B cells, CD8+ T cells, and natural killer T cells) were all inactivated in high-risk patients, suggesting that m7G-related lncRNAs may be related to the immunosuppressive tumor microenvironment in LIHC.