Hence, we analyzed the relationships between the signature and TIP-related genes, and the results showed that cold tumor genes such as CXCL2 and CCL20 and hot tumor genes such as CXCR3, CXCL11, and PDCD1 were upregulated in the high-risk group in both cohorts (Figures 9B,D). The gene discussed is CXCL2; the disease is neoplasm.