Jia and her colleagues (Jia et al., 2011a) proved the m6A is the substrate of fat mass and obesity-related proteins (FTO), and the FTO will induce the demethylation of m6A. FTO can oxidize m6A in an indirect way, which will generate two intermediates: hm6A and f6A (Jia et al., 2011b). The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.