CD274 and neoplasm: Recent research has found that PD-L1 expression measured by immunohistochemistry (IHC) and tumor mutation burden (TMB) measured by whole exome sequencing (WES) are not reliable predictors of ICB response in a variety of tumor types (Merino et al., 2020) (McGrail, Pilié, Rashid, Voorwerk, Slagter, Kok, et al.).