CD4 and cancer: Moreover, the expression levels of GZMB were found to be positively correlated with the infiltration levels of CD8 + T cells, plasma cells, dendritic cells (DCs), CD4 + T cells, monocytes, NK cells, macrophages, neutrophils, endothelial cells, and cancer-associated fibroblast cells were negatively associated with regulatory T cells (Tregs) (Supplementary Figure S11C).