As shown in Figure 2G, Cluster A was significantly related to lower TNM stage (p < 0.01), right-sided CRC (p < 0.001), higher deficient mismatch repair (dMMR) (p < 0.001), without TP53 (p < 0.01) and BRAF mutations (p < 0.001), and lower recurrence risk (p < 0.05) compared to those in Cluster B. Given the significant influence of PRG expression on the function of immunity (Figures 1I,J), we next investigated the distinct characteristics of the TME infiltration between Cluster A and Cluster B. The gene discussed is BRAF; the disease is colorectal carcinoma.