Notably, we discovered that the expression levels of most PRGs were positively correlated with CNV alteration, such as CASP1, CASP3, CASP6, GZMA, GSDMB, and NLRP1 were expressed at lower levels in CRC samples compared with normal samples, while GSDMC and CASP8 were significantly elevated in CRC samples. This evidence concerns the gene CASP8 and colorectal carcinoma.