CD8A and intervertebral disk degenerative disorder: By Wilcoxon rank-sum test, we found that the abundance of neutrophils, Tem, and TReg was significantly higher in the IDD group than in the normal group; whereas CD8 T cells, cytotoxic cells, NK cells, T cells, T helper cells, Tgd, and Th2 cells in the normal group were accounted for a higher percentage (Figure 9A).