Under stress conditions such as hypoxia (Law et al., 2008; Law and Wong 2010), ER stress (Joshi et al., 2015), and nutrient deprivation (He et al., 2019), both transcriptional and post transcription of STC2 were regulated, and in turn drives tumor cell growth, proliferation, and tumorigenesis. The gene discussed is STC2; the disease is neoplasm.