Previous findings described the upregulation of BCR on the cell surface resulting in NF-κB signaling activation via tyrosine protein kinase (LYN), tyrosine kinase in the spleen (SYK), and the tyrosine kinase of Bruton (BTK), which inhibits B cell apoptosis and promotes proliferation in lymphoma cells [15, 16]. This evidence concerns the gene NFKB1 and lymphoma.