Many studies have also revealed other mechanisms involved in the regulation of MDD by NLRP3 inflammasomes in microglia, which may be related to dysregulation of miRNA-27a/SYK/NF-κB pathway, nuclear factor-erythroid 2 -related factor 2 (Nrf2) (Ajami et al., 2011; Eggen et al., 2013; Arioz et al., 2019; Li et al., 2021a). This evidence concerns the gene NFE2L2 and major depressive disorder.