Furthermore, in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice, baicalein inhibited NLRP3/caspase-1/GSDMD pathway-mediated microglia pyroptosis, thereby reducing PD symptoms (Rui et al., 2020). The gene discussed is GSDMD; the disease is Parkinson disease.