OM-MSCs have immunomodulatory and reparative functions and replace or repair damaged cells, and OM-MSCs upregulate the expression and release of HIF-1α under OGD/R conditions, suppressing the expression of NLRP3 inflammasome and pyroptosis-related proteins in co-cultured BV2 microglia and reducing the pyroptosis of BV2 microglia under OGD/R conditions (Coppin et al., 2019; Dabrowska et al., 2019; Huang et al., 2020). The gene discussed is HIF1A; the disease is ocular melanoma.