GSDMD and myeloid sarcoma: This study found that caspase-1 activates caspase-3/7 in MS patients and EAE mouse models, and caspase-3/7 and its substrates, such as PARP, DFF45 and ROCK1, after cleavage activation, induce GSDMD-mediated microglial cell pyroptosis by disrupting the cellular protein hydrolysis network and promoting microglial cell nuclear cohesion glial cell pyroptosis (McKenzie et al., 2020b).