IL1B and Anxiety: Prenatal treatment with LPS (125 μg/kg in mice; 1.5 mg/kg in rats) also triggered overexpression of IL-1β, IL-6, IL-10, and TNF-α in the placenta and fetal brain, which were related to abnormal microglial numbers, altered cytokine gene expression, anxiety-like behavior and disrupted social behavioral patterns in neonates and adult offspring (Lacabanne, 2018; Talukdar et al., 2020).