Indeed, due to the Aβ-amyloid precursor protein gene (APP; the same gene implicated in familial AD) triplication in chromosome 21, amyloid deposition can be found in virtually all individuals with DS by their third decade (Davidson et al., 2018), several years earlier than the pathology development in the general population (sporadic Alzheimer disease, sAD). This evidence concerns the gene APP and Dravet syndrome.