ADIPOQ and obstructive sleep apnea syndrome: For instance, in patients with severe Obstructive Sleep Apnea (OSA), the adiponectin levels in serum are higher before sleep time than after (Nakagawa et al., 2008), and OSA subjects show fragmented sleep with overall low-quality (Mutairi et al., 2014; Lu et al., 2019) in agreement with the hypothesis that adiponectin affects the quality of sleep.