In addition, it includes bisphosphonate, bone disease, bone metastasis, bone remodeling, breast cancer, cancer, denosumab, double-blind, etc. The fifth cluster is purple, with 19 terms covering molecular regulation mechanisms, including activation, induction, differentiation, osteoclast, and NFATC-1, c-Fos. The gene discussed is NFATC1; the disease is breast carcinoma.