CD8A and non-proliferative diabetic retinopathy: Figures 1A, B revealed the composition results obtained from 19 macular samples of DR patients. The CD8+T cell infiltration was significantly higher in the DME group than in the NPDR group (Figure 1C, p = 0.019). A total of 2221 DEGs were obtained by performing edgeR package for differential analysis combined with correlation analysis (p < 0.05), among which 371 DEGs were highly correlated with CD8+T cell abundance (PCC > 0.6) and were identified as DECD8+TRGs (Figure 1D).