Ultimately, nine DEGs with consistent expression profiles in blood and kidney biopsy samples from patients with DKD were identified: which included Alpha-2A adrenergic receptor (ADRA2A), C-C motif chemokine 5 (CCL5), cholesterol 25-hydroxylase (CH25H), C-X-C chemokine receptor type 4 (CXCR4), hemoglobin subunit delta (HBD), hydroxycarboxylic acid receptor 3 (HCAR3), lysophosphatidylcholine acyltransferase 1 (LPCAT1), Lithostathine-1-alpha (REG1A), and Runt-related transcription factor 3 (RUNX3). This evidence concerns the gene HCAR3 and diabetic kidney disease.