ADORA2A and essential hypertension, genetic: Given that the DBP hyperreactivity to NE-infusion observed in our HT was eliminated by prior α-AR blockade by PHE resulting in similar DBP reactivity to NE-infusion after α-AR blockade in HT and NT, it can be assumed that the DBP hyperreactivity to NE in EHT is mediated via α1- and α2-AR.