CD8A and type 1 diabetes mellitus: have found that compared with the T1D group, the frequency of peripheral islet antigen-specific autoreactive CD8+ T cells in the LADA group is lower and the central-memory subset is relatively restrained under in vitro stimulation with pancreatic β cell-associated antigen, and thus the autoreactive CD8+ T cells in LADA had inferior proliferative capacity, but their function was comparable between the two groups (24).