Module 1 consists of five pathways, including lipid and atherosclerosis (hsa05417), Yersinia infection (hsa05135), signaling pathway of C-type lectin receptor (hsa04625), Chagas disease (hsa05142), signaling pathway (AGE-RAGE) in diabetic complications (hsa04933). The gene discussed is CLEC4D; the disease is atherosclerosis.