To conclude, melatonin treatment could alleviate the complications of LR-induced obesity by regulating the top 10 targets (TP53, AKT1, MAPK3, PTGS2, TNF, IL6, MAPK1, ERBB2, IL1B, MTOR). The gene discussed is MAPK3; the disease is obesity due to melanocortin 4 receptor deficiency.