Since a decline in the number of oocyte as well as the increase of age, old age (37) and embryo aneuploidy (38) are crucial factors of infertility, the GnRH agonist long-acting protocol is recommended for infertile women with normal ovarian reserve, who have BMI<24kg/m2 and are aged <30 years old as well as those who have normal ovarian reserve have BMI ≥ 24kg/m2 and are aged ≥ 30 years. The gene discussed is GNRH1; the disease is Infertility.