Compared with the control group, the expressions of AIF-1, CCR2, and p-NF-κB p65 in the blood vessels of the mice in the CKD group were increased, but the change of NF-κB p65 expression was not significant, indicating that Aldo-induced vascular calcification in CKD was accompanied by inflammation and activation of NF-κB p65. The gene discussed is NFKB1; the disease is chronic kidney disease.