Abnormalities in gonadotropin-releasing hormone (GnRH) secretion (2, 3) result in hypogonadotropic hypogonadism with impaired luteinizing hormone (LH) pulsatile secretion (4–8), and insufficient LH and follicle-stimulating hormone (FSH) concentrations (5, 9) to maintain full folliculogenesis and therefore ovulatory function, and the condition is also referred to as functional hypogonadotropic hypogonadism. Here, BRD2 is linked to hypogonadotropic hypogonadism.