Using murine oral cancer (MOC) C57BL/6 syngeneic tumor models, PI3Kδ/γ inhibition or anti-Ly6G depletion inhibits the impact of the expanded myeloid populations and enhances responses to PD-L1 mAb in T-cell–inflamed MOC1, but not in non-T-cell–inflamed MOC2 tumors [172]. This evidence concerns the gene CD274 and lip and oral cavity carcinoma.