In contrast, variants at DPP9, FOXP4 or TYK2 loci with reported effects on several autoimmune-related diseases (Kichaev et al., 2019) or inflammatory-related loci (e.g. CXCR6, LZTFL1, IFNAR2 and OAS1/OAS2/OAS3 loci) and specially the 3p21.31 locus have been described to have an huge impact on COVID19 severity (Niemi et al., 2021). The gene discussed is CXCR6; the disease is COVID-19.