ACE2 and COVID-19: Given the potential impact of shortlisted ACE2 variants in SARS-CoV-2 infection and its overrepresentation in Mediterranean populations (Benetti et al., 2020; Vadgama et al., 2022), we analyzed the presence of these variants in severity-stratified groups from our cohort in order to get an insight on the role of ACE2 variants on interindividual severity and susceptibility to COVID-19.