Compared to the control group, 5-LO deficient mice had a greater periapical bone damage area, and significantly increased levels of inflammatory factors and osteoclast-forming factors, including TNF-α, IL-1β, and RANKL, while OPG was decreased, suggesting that the innate immune system of mice with 5-LO deficiency was damaged and periapical inflammation was aggravated (Wu et al., 2018). This evidence concerns the gene TNFSF11 and inflammatory response.