IL-10 is a cytokine associated with the induction of a phagocytic and permissive macrophage phenotype in leprosy patients (Montoya et al., 2009; de Oliveira Fulco et al., 2014) and we can suggest that the regulation of TREM2 after MDT in MB patients may impact the outcome of the treatment. The gene discussed is TREM2; the disease is leprosy.