Furthermore, an inverse correlation between HUWE1 and p53 expression in colorectal carcinoma progression was identified, suggesting that HUWE1 mediated the ubiquitination and proteasomal degradation of p53, although the direct interaction between HUWE1 and p53 was not defined in that study (Yoon et al., 2005). This evidence concerns the gene TP53 and colorectal carcinoma.