HUWE1 and Familial prostate cancer: However, in prostate cancer cell lines, HUWE1 overexpression was found to inhibit cell proliferation, cell migration and explant growth, and c-Myc was downregulated in human prostate cancer (CaP) cells with high HUWE1 expression (Qu et al., 2018), suggesting that HUWE1 functioned as a tumor suppressor by negatively regulating c-Myc activity.