Furthermore, obesity is associated with a low-grade inflammation status, and adipose tissue can secrete several proinflammatory factors, such as C-reactive protein, tumor necrosis factor-α, and interleukin-6, which may exert crucial functions in the pathogenesis of OPLL or OLF (31, 32). The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.