Furthermore, obesity is associated with a low-grade inflammation status, and adipose tissue can secrete several proinflammatory factors, such as C-reactive protein, tumor necrosis factor-α, and interleukin-6, which may exert crucial functions in the pathogenesis of OPLL or OLF (31, 32). The gene discussed is CRP; the disease is ossification of the posterior longitudinal ligament of the spine.