In TCGA database of ESCA, compared with 11 normal tissues, ESM1 was highly expressed in 162 tumor tissues (p < 0.001, see Figure 1(b)), and ESM1 expression in 11 of 162 tumor tissues was also higher than that in 11 paired adjacent tissues (p < 0.001, see Figure 1(c)). Here, ESM1 is linked to neoplasm.