Hernandez et al. have shown that patients with a pathogenic de novo pathogenic variant of GABRA1 have a broad phenotypic range of severe EOEEs, such as West syndrome, Dravet syndrome, Ohtahara syndrome and epilepsy with myoclonic atonic seizures (formerly known as Doose syndrome) (16). The gene discussed is GABRA1; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.