In previous research, targeted resequencing was performed in sixty-seven patients with Dravet syndrome of typical disease progression and three pathogenic variants of GABRA1 were detected in four patients (c.751G> A, p.G251S *1; c.335G> A, p.R112Q*2; c.917A> C, p.K306T*1) (23). The gene discussed is GABRA1; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.