To achieve an antigen-specific cellular and humoral response using a COVID-19 gp96-Ig vaccine approach, without using recombinant S protein, we generated a cell line that expresses full length S protein in addition to secreted gp96-Ig (Fig. 1c) and OX40L-Fc (Fig. 1d). The gene discussed is TNFSF4; the disease is COVID-19.