INS and obesity due to melanocortin 4 receptor deficiency: The PPARGC1A gene rs8192678 polymorphism has been previously related to the development of obesity (Mirzaei et al., 2012; Franks et al., 2014; Costa-Urrutia et al., 2018; Zamaninour et al., 2018), biochemical parameters such as glucose, insulin, triglycerides and inflammatory markers, resting energy expenditure (Mirzaei et al., 2012), and physical fitness level (Costa-Urrutia et al., 2018).