Recent research revealed that Wnt/β-catenin may affect the transcription and expression of c-Myc proteins via the nuclear translocation of β-catenin when myocardial injuries occur, including dilated cardiomyopathy and ischemic cardiomyopathy, and participate in myocardial remodeling under abnormal conditions (Hou et al., 2016; Piven and Winata, 2017). Here, MYC is linked to ischemic cardiomyopathy.