SIRT1 and Parkinson disease: It has been described that SIRT1 deacetylates peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), a key regulator of mitochondrial biogenesis and potential target for therapy in PD patients (Nemoto et al., 2005; Zheng et al., 2010; Wang et al., 2015).