While studies have indicated that SIRT1 induces positive effects on depressive-like behaviors as well as general synaptic function and ultrastructure in chronic unpredictable stress models (Abe-Higuchi et al., 2016; Shen et al., 2019; Lei et al., 2020), inhibition of SIRT1 expression reversed decreases in spine density within the ventral hippocampal CA1 region in a model of post-traumatic stress disorder (Li et al., 2019). This evidence concerns the gene SIRT1 and post-traumatic stress disorder.