Or that cathepsin B led to collective invasion in salivary cystic adenoid carcinoma (Wu et al., 2019) the inhibition of Rho-associated protein kinase 2 (ROCK2) associated with the initiation of collective invasion in colorectal adenocarcinoma (Libanje et al., 2019), and the loss of heat shock factor 2 (HSF2) correlated with collective invasion in prostate cancer (Björk et al., 2016). This evidence concerns the gene ROCK2 and Familial prostate cancer.