(Martin et al., 2021) Structural biological studies of the SARS-CoV-2 S1-RBD proposes that N501Y mutation may increase its affinity for ACE2 binding (Starr et al., 2020; Ostrov, 2021) and that the open conformation of the N501Y mutant spike protein (Teruel et al., 2021) is associated with more efficient viral entry, transmission and infection (Leung et al., 2021). Here, ACE2 is linked to infection.