One study indicated that Nrf2 knockout may reduce Nrf2 entry into the nucleus and fail to initiate the transcription of downstream molecules, thereby exacerbating inflammation and autophagy in a severe pancreatitis induced acute lung injury model; however, the expression of Keap1 was higher in Nrf2−/− mice than in WT mice (Kong et al., 2021). Here, NFE2L2 is linked to pancreatitis.