A previous study had reported the failure of metal homeostasis in the liver and spleen from a mouse model of NPCD (Hung et al., 2014), and there have been many evidence about autophagy regulating iron content (Park and Chung, 2019), and we thus wondered whether NPC1 deficiency induced iron metabolic disorder in auditory cells through autophagy. Here, NPC1 is linked to metabolic disease.