ITCH and neoplasm: For example, Wang et al. observed that circ-ITCH overexpression significantly inhibited the proliferation and invasion of PTC cells by upregulating the expression of CBL and promoting apoptosis in vitro, which led to suppression of the Wnt/β-catenin pathway and the tumour-suppressive role of circ-ITCH (Wang M. et al., 2018).